Which condition is most likely to cause pain or tenderness in the affected area?

Cellulitis is an infection of the skin and the underlying soft tissues, typically resulting from bacteria penetrating through a break in the skin. This condition often presents with symptoms such as swelling, redness, warmth, and significant pain or tenderness in the affected area. The presence of infection leads to inflammation, which is a key factor in the discomfort experienced. Thus, it is the condition most likely to cause pain or tenderness.

In contrast, warts are benign growths caused by the human papillomavirus (HPV) and generally do not cause pain unless they are subjected to pressure or friction. Folliculitis, which is the inflammation of hair follicles, can cause some tenderness, but it tends to be localized and less severe than the pain associated with cellulitis. Herpes simplex can cause discomfort, particularly during an outbreak, but it typically involves localized tingling or itching more than generalized pain in the way cellulitis does.